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Degradation of the cyclin-dependent kinase inhibitor KRP1 is regulated by two different ubiquitin E3 ligases.
Ren, Hong; Santner, Aaron; del Pozo, Juan Carlos; Murray, James A H; Estelle, Mark.
Afiliação
  • Ren H; Department of Biology, Indiana University, Bloomington, IN 47405, USA.
Plant J ; 53(5): 705-16, 2008 Mar.
Article em En | MEDLINE | ID: mdl-18005227
ABSTRACT
In animals and fungi, a group of proteins called the cyclin-dependent kinase inhibitors play a key role in cell cycle regulation. However, comparatively little is known about the role of these proteins in plant cell cycle regulation. To gain insight into the mechanisms by which the plant cell cycle is regulated, we studied the cyclin-dependent kinase inhibitor KRP1 in Arabidopsis. KRP1 interacts with the CDKA;1/CYCD2;1 complex in planta and functions in the G1-S transition of the cell cycle. Furthermore, we show that KRP1 is a likely target of the ubiquitin/proteasome pathway. Two different ubiquitin protein ligases, SCF(SKP2) and the RING protein RKP, contribute to its degradation. These results suggest that SCF(SKP2b) and RPK play an important role in the cell cycle through regulating KRP1 protein turnover.
Assuntos
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Base de dados: MEDLINE Assunto principal: Arabidopsis / Quinases Ciclina-Dependentes / Proteínas de Arabidopsis / Ubiquitina-Proteína Ligases / Proteínas Inibidoras de Quinase Dependente de Ciclina Idioma: En Ano de publicação: 2008 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Arabidopsis / Quinases Ciclina-Dependentes / Proteínas de Arabidopsis / Ubiquitina-Proteína Ligases / Proteínas Inibidoras de Quinase Dependente de Ciclina Idioma: En Ano de publicação: 2008 Tipo de documento: Article