Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
Bioorg Med Chem Lett
; 18(1): 318-23, 2008 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-18006306
ABSTRACT
The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Bifenilo
/
Proteínas Quinases p38 Ativadas por Mitógeno
/
Inibidores de Proteínas Quinases
/
Amidas
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article