PKC signaling in oxidative hepatic damage.
Mol Aspects Med
; 29(1-2): 36-42, 2008.
Article
em En
| MEDLINE
| ID: mdl-18035409
ABSTRACT
Protein kinase C (PKC) is a family of isoenzymes differently involved in cell response to injury and many studies describe their role as "stress sensors". Oxidative stress is strictly involved in the pathogenesis of chronic liver diseases including alcohol- or drug-induced hepatotoxicity, iron overload, hepatitis and hepatocarcinoma development, but molecular mechanisms are not really defined. A crucial role of PKC as a redox sensitive signaling molecule has been widely accepted.
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Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
/
Transdução de Sinais
/
Estresse Oxidativo
/
Fígado
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article