DNA methylation patterns of the CDH1, RARB, and SFN genes in choroid plexus tumors.
Cancer Genet Cytogenet
; 179(2): 140-5, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-18036402
ABSTRACT
Genetic and epigenetic alterations in choroid plexus tumors, a rare neuroepithelial neoplasm most frequently detected in children, are poorly characterized. Epigenetic silencing associated with aberrant CpG island methylation is one mechanism leading to the loss of tumor suppressor functions in cancer cells. Using methylation-specific polymerase chain reaction, the methylation patterns of the genes CDH1 (E-cadherin), RARB (retinoic acid receptor, beta), and SFN (stratifin; 14-3-3sigma) were retrospectively investigated in eight choroid plexus tumors (five papillomas, two atypical papillomas, and one carcinoma), as well as in two normal cortexes obtained after autopsy from male individuals aged 6 months and 64 years. Among the six pediatric tumors, the mean age at diagnosis was 1.8 years old (range, 0.2-6) and the two adult tumors were detected in a 66-year-old man and a 45-year-old woman. A high frequency of hypermethylation was detected in CDH1 and SFN genes in tumoral and normal cortex tissues. Tumor-specific RARB hypermethylation was observed in four papillomas. Further studies are required to evaluate the role of aberrant methylation in choroid plexus tumor progression.
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Caderinas
/
Neoplasias do Plexo Corióideo
/
Receptores do Ácido Retinoico
/
Metilação de DNA
/
Exonucleases
/
Proteínas de Neoplasias
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
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Infant
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article