Calcitonin gene-related peptide (CGRP) receptor antagonists: investigations of a pyridinone template.
Bioorg Med Chem Lett
; 18(2): 755-8, 2008 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-18039571
ABSTRACT
In our effort to find potent, orally bioavailable CGRP receptor antagonists for the treatment of migraine, a novel series based on a pyridinone template was investigated. After optimizing the privileged structure and the placement of the attached phenyl ring, systematic SAR was carried out on both the N-alkyl and C-5 aryl substituents. Several analogs with good potency and pharmacokinetic profiles were identified.
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Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Antagonistas do Receptor do Peptídeo Relacionado ao Gene de Calcitonina
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article