Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice.
Mol Cell Endocrinol
; 280(1-2): 39-46, 2008 Jan 02.
Article
em En
| MEDLINE
| ID: mdl-18045774
ABSTRACT
The A-ZIP/F-1 transgenic mouse is a model of lipoatrophic diabetes with severe insulin resistance, hyperglycemia and hyperlipidemia. Recently, a regulatory role of adipose tissue on adrenal gland function and blood pressure has been suggested. To further explore the importance of adipose tissue in the regulation of adrenal function and blood pressure, we studied this mouse model of lipodystrophy. A-ZIP/F-1 mice exhibit significantly elevated systolic and diastolic blood pressure values despite lack of white adipose tissue and its hormones. Furthermore, A-ZIP/F-1 lipoatrophic mice have a significant reduction of adrenal zona glomerulosa, while plasma aldosterone levels and aldosterone synthase mRNA expression remain unchanged. On the other hand, lipoatrophic mice present elevated corticosterone levels but no adrenocortical hyperplasia. Ultrastructural analysis of adrenal gland show significant alterations in adrenocortical cells, with conformational changes of mitochondrial internal membranes and high amounts of liposomes. In conclusion, lipodystrophy in A-ZIP/F-1 mice is associated with hypertension, possibly due to hypercorticosteronemia and/or others metabolic-vascular changes.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Córtex Suprarrenal
/
Diabetes Mellitus Lipoatrófica
/
Tecido Adiposo Branco
/
Hipertensão
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article