CsoR regulates the copper efflux operon copZA in Bacillus subtilis.
Microbiology (Reading)
; 153(Pt 12): 4123-4128, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-18048925
ABSTRACT
The adaptation of Bacillus subtilis to elevated levels of copper ions requires the copper-inducible copZA operon encoding a copper chaperone and efflux ATPase. Here we identify CsoR (formerly YvgZ) as the copper-sensing repressor that regulates the copZA operon. CsoR binds with high affinity to an operator site overlapping the copZA promoter and its binding is specifically inhibited by copper salts. As previously described, the YhdQ (CueR) protein also binds to the copZA regulatory region, but genetic experiments indicate that this protein is not responsible for the copper-dependent regulation of this operon.
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Base de dados:
MEDLINE
Assunto principal:
Óperon
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Bacillus subtilis
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Proteínas de Bactérias
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Regulação Bacteriana da Expressão Gênica
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Adenosina Trifosfatases
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Chaperonas Moleculares
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Cobre
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article