Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound.
Eur J Gastroenterol Hepatol
; 19(11): 919-22, 2007 Nov.
Article
em En
| MEDLINE
| ID: mdl-18049158
ABSTRACT
Among industrialized countries, the rate of drug-induced liver failure varies widely accounting for about 1-12% of the indications for liver transplantation. Nonsteroidal anti-inflammatory drugs (NSAIDs) are with antibiotics the most frequently involved compounds. In this single-center series of 57 consecutive cases of acute liver failure treated by orthotopic liver transplantation, five were related to NSAIDs-induced liver damage, three being due to nimesulide use. This has to be taken as a further warning about the potential for this compound to induce liver failure.
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Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Anti-Inflamatórios não Esteroides
/
Transplante de Fígado
/
Doença Hepática Induzida por Substâncias e Drogas
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article