Expression profiling identifies a molecular signature of reactive astrocytes stimulated by cyclic AMP or proinflammatory cytokines.
Exp Neurol
; 210(1): 261-7, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18054918
ABSTRACT
Specialized glia, termed reactive astrocytes, accompany numerous pathologic conditions affecting the central nervous system, including stroke, multiple sclerosis, and neoplasia. To better define this important cell type, we employed high-density microarray gene expression profiling using two in vitro models of reactive gliosis (stimulation with dbcAMP or IL-1beta/IFNgamma). We identified 44 differentially expressed transcripts common to both in vitro models and demonstrated that a subset of these genes are also differentially expressed in response to experimental autoimmune encephalomyelitis and focal cerebral ischemia in vivo. Moreover, this pattern of differential gene expression is not observed in hyperproliferating or neoplastic glia.
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Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Astrócitos
/
Citocinas
/
AMP Cíclico
/
Perfilação da Expressão Gênica
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article