Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK.
Antiviral Res
; 77(2): 150-2, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18055026
ABSTRACT
The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, L132 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Cloroquina
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Coronavirus Humano 229E
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MAP Quinases Reguladas por Sinal Extracelular
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Proteínas Quinases p38 Ativadas por Mitógeno
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Células Epiteliais
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Pulmão
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article