The carotid bodies influence growth responses to moderate maternal undernutrition in late-gestation fetal sheep.
BJOG
; 115(2): 261-8, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-18081604
ABSTRACT
OBJECTIVE:
To determine the role of carotid sinus innervation on differential fetal organ growth during maternal nutrient restriction in late pregnancy.DESIGN:
Randomised controlled study.SETTING:
University research facility. SAMPLE Thirty-nine Merino ewes.METHODS:
At 113 days gestational age (dGA), fetuses were bilaterally carotid sinus denervated or sham denervated. From 118 dGA, the surgery groups were subdivided into two dietary groups, and their ewes were fed 100% of nutrient requirements or 50% until tissue collection at 140 dGA. This provided four groups (sham/control diet, sham/restricted diet, denervated/control diet and denervated/restricted diet). MAIN OUTCOMEMEASURES:
Fetal organ weights and hormone levels and maternal weight change during the dietary restriction.RESULTS:
Adrenal glands were larger in sham/restricted diet fetuses than in sham/control diet or denervated/restricted diet fetuses (P < 0.05). Fetal adrenal weight and brain-to-liver weight ratio were positively related to maternal weight change during the nutritional challenge in sham fetuses only (P < 0.05). Fetal liver weight was negatively related to maternal weight change during nutritional challenge in sham fetuses only (P < 0.05).CONCLUSIONS:
We have shown a reduction in liver growth but sparing of adrenal growth in response to moderate maternal undernutrition, which is dependent on intact carotid body innervation. This suggests a new role for the carotid bodies in the control of differential organ growth during such undernutrition.
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Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Seio Carotídeo
/
Desnutrição
/
Desenvolvimento Fetal
/
Dieta Redutora
Limite:
Animals
/
Pregnancy
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article