Novel mechanisms in accelerated atherosclerosis in kidney disease.
J Ren Nutr
; 18(1): 65-9, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-18089447
ABSTRACT
OBJECTIVE:
Urea undergoes a spontaneous, nonenzymatic transformation to cyanate, the active part of which is isocyanic acid, which can cause modifications of a variety of proteins in a process called carbamylation. We postulated that, in patients with renal disease, the carbamylation of low-density lipoprotein (LDL) is a nontraditional risk factor for cardiovascular disease, and that elevated urea leads to carbamylated LDL (cLDL), which causes vascular injury and leads to atherosclerosis.RESULTS:
We showed that carbamylated LDL manifests all of the biological effects relevant to atherosclerosis, including endothelial-cell injury, the expression of adhesion molecules, and vascular smooth muscle cell proliferation. We also developed an enzyme-linked immunosorbent assay to measure carbamylated LDL in patients, and showed that cLDL is markedly elevated in dialysis patients.CONCLUSIONS:
Our data indicate that cLDL may be an important nontraditional risk factor for atherosclerosis in patients with kidney disease.
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Base de dados:
MEDLINE
Assunto principal:
Aterosclerose
/
Nefropatias
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article