A terphenyl scaffold for pi-stacked guanidinium recognition elements.
Org Lett
; 10(2): 297-300, 2008 Jan 17.
Article
em En
| MEDLINE
| ID: mdl-18092794
ABSTRACT
A new synthetic model of arginine-carboxylate-aromatic triads-common motifs at sites of protein-protein interactions-is reported. Binding studies in mixed methanol/water solvent systems suggest that the carboxylate-binding ability of pi-stacked guanidinium ions is improved relative to a non-stacked control.
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Terfenil
/
Modelos Moleculares
/
Guanidina
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article