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Mass spectrometry-based proteomics of fungal wall glycoproteins.
Yin, Qing Yuan; de Groot, Piet W J; de Koster, Chris G; Klis, Frans M.
Afiliação
  • Yin QY; Swammerdam Institute for Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands.
Trends Microbiol ; 16(1): 20-6, 2008 Jan.
Article em En | MEDLINE | ID: mdl-18096391
The manifold functions of fungal wall glycoproteins include maintenance of cell wall integrity, homotypic and heterotypic adhesion, biofilm formation, acquisition of iron and sterols, protein degradation and coping with oxidative stress. Transcriptome studies indicate that the expression levels of most cell wall glycoproteins can vary widely and are tightly controlled. However, owing to their complex and variable glycosylation, fungal wall glycoproteins are difficult to analyze using traditional proteomics approaches. Recent advances in mass spectrometry-based proteomics have enabled rapid and sensitive identification and quantitation of fungal wall glycoproteins; this will be particularly useful for studying the dynamics of the subproteome of fungal wall glycoproteins, and for the development of novel vaccines and diagnostic tools.
Assuntos
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Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Proteínas Fúngicas / Glicoproteínas / Parede Celular / Proteômica / Fungos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2008 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Proteínas Fúngicas / Glicoproteínas / Parede Celular / Proteômica / Fungos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2008 Tipo de documento: Article