The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding.
Asian J Androl
; 10(4): 593-601, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18097508
ABSTRACT
AIM:
to investigate the effects of crude garlic on adult male rat reproductive functions.METHODS:
Thirty male rats were divided into five groups group 1 (untreated) and groups 2, 3, 4 and 5 were fed for 30 days with 5%, 10%, 15% and 30% crude garlic, respectively. Testes and accessory organs were weighed and some markers were assessed. Light and electron microscopy observations were also performed.RESULTS:
A significant decrease was observed in the body weight of groups 4 (14%; P < 0.01) and 5 (20%; P < 0.01); of the prostate weight in group 5 (29.1%; P < 0.05) and of seminal vesicle weight in groups 3 (14.4%; P < 0.01), 4 (18.3%; P < 0.01) and 5 (27.3%; P < 0.01). In contrast, testis and epididymis weights were unchanged. In epididymis tissue, the alpha glucosidase activity and the spermatozoa density were unchanged. The treatment resulted in a significant decrease in testosterone serum levels in groups 3 (77.3%; P < 0.01), 4 (77.3%; P < 0.01) and 5 (90.9%; P < 0.01), associated with a significant increase in LH serum levels (P < 0.01). Testicular histology showed a dose-dependent increase in the percentage of empty seminiferous tubules. Moreover, testicular function was affected; a significant decrease in phosphatase acid activity (P < 0.01) and testosterone (P < 0.05) contents were observed.CONCLUSION:
Crude garlic consumption during 1 month reduced testosterone secretion and altered spermatogenesis at 10%, 15% and 30% doses.
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Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Testículo
/
Preparações de Plantas
/
Alho
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article