Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase.
Antiviral Res
; 16(4): 295-305, 1991 Dec.
Article
em En
| MEDLINE
| ID: mdl-1810306
ABSTRACT
Ro 31-8959 inhibits the spread of HIV infection and the production of cytopathic effects in cultures of acutely infected cells. IC50 values for these effects are in the range 0.5-6.0 nM and IC90 values are in the range 6.0-30.0 nM. This inhibitor is effective even when added to cultures at a late stage of infection, after syncytia have started to form. Virus antigen, virus particles and virus cytopathic effects can largely be cleared from cultures treated with compound from 3 days until 6 days post infection. In chronically-infected cells, inhibition of virus maturation can be detected after 24 hours' treatment with 10 nM Ro 31-8959. In addition, a significant reduction of the proteolytic processing of p56 to p24 can be demonstrated in these cells with compound at picomolar concentrations. These properties indicate that Ro 31-8959 is highly effective against HIV with the potential to inhibit acute, established acute and chronic infections.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Infecções por HIV
/
Inibidores da Protease de HIV
Limite:
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article