Molecular basis for skeletal variation: insights from developmental genetic studies in mice.
Birth Defects Res B Dev Reprod Toxicol
; 80(6): 425-50, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-18157899
ABSTRACT
Skeletal variations are common in humans, and potentially are caused by genetic as well as environmental factors. We here review molecular principles in skeletal development to develop a knowledge base of possible alterations that could explain variations in skeletal element number, shape or size. Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anormalidades Induzidas por Medicamentos
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Osso e Ossos
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Desenvolvimento Ósseo
Limite:
Animals
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article