Nogo receptor antagonizes p75NTR-dependent motor neuron death.
Proc Natl Acad Sci U S A
; 105(2): 740-5, 2008 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-18182498
ABSTRACT
The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nervo Isquiático
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Regulação da Expressão Gênica
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Morte Celular
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Receptores de Fator de Crescimento Neural
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Receptores de Superfície Celular
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Proteínas da Mielina
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Degeneração Neural
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article