Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity.
J Virol
; 82(6): 3135-8, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18184712
ABSTRACT
Correlates of protection from rotavirus infection are controversial. We compared the roles of B and T lymphocytes in protective immunity induced either by intranasally administered nonreplicating viruslike particles or inactivated virus or by orally administered murine rotavirus. We found that protection induced by nonreplicating vaccines requires CD4(+) T cells and CD40/CD40L. In contrast, T cells were not required for short-term protective immunity induced by infection, but both T-cell-dependent and -independent mechanisms contributed to long-term maintenance of protection. Our findings indicate that more than one marker of protective immunity exists and that these markers depend on the vaccine that is administered.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírion
/
Linfócitos T
/
Rotavirus
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article