Failure of a new antivenom to treat Echis ocellatus snake bite in rural Ghana: the importance of quality surveillance.
Trans R Soc Trop Med Hyg
; 102(5): 445-50, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18190937
ABSTRACT
This study compares two antivenoms used to treat Echis ocellatus snake bite patients at Mathias Hospital, Yeji, central Ghana. FAV-Afrique antivenom (Aventis Pasteur) was given to 278 patients during 2001--2003, whilst Asna Antivenom C (Bharat Serum and Vaccines Ltd) was used in 2004 to treat 66 patients. The two groups had comparable patient attributes, time from snake bite to treatment and staff adherence to the tested treatment protocol. The antivenom C group required more repeat doses and twice the amount of antivenom to treat coagulopathy. Of greater concern, the antivenom C mortality rate was 12.1%, a marked rise from the 1.8% rate in the earlier FAV-Afrique antivenom group. In this study, antivenom C was ineffective as treatment for West African E. ocellatus snake venom. This illustrates the absolute need for regional pilot tests to assess the effectiveness of a new antivenom against local snake venoms before its sole and general distribution in a region is initiated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mordeduras de Serpentes
/
Venenos de Víboras
/
Antivenenos
/
Monitoramento de Medicamentos
/
Viperidae
Tipo de estudo:
Guideline
/
Screening_studies
Limite:
Adult
/
Animals
/
Female
/
Humans
/
Male
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article