Vdelta2 T-lymphocyte responses in cord blood samples from Italy and Côte d'Ivoire.
Immunology
; 124(3): 380-7, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18194269
ABSTRACT
Cord blood T lymphocytes are immature and their functional defect partially reflects a suboptimal level of costimulatory signals provided by neonatal antigen-presenting cells. Neonatal Vdelta2 T lymphocytes, a small component of cellular immunity involved in the response against bacteria, protozoa, virus-infected cells and tumours, are also considered to be immature. Cord blood Vdelta2 T lymphocytes are mostly naïve, proliferate poorly and do not produce cytokines in response to the model phosphoantigen isopentenyl pyrophosphate. We cultured cord blood mononuclear cells with the aminobisphosphonate Pamidronate or with live bacille Calmette-Guérin, and showed that both elicit a strong cord blood Vdelta2 T-cell proliferative response, inducing the expression of activation markers and promoting the differentiation from naïve to memory cells. Our results suggest that cord blood Vdelta2 T cells are not inherently unresponsive and can mount strong responses to aminobisphosphonates and mycobacteria. Neonatal Vdelta2 T lymphocytes may be important participants in responses to microbial infections early in life.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Subpopulações de Linfócitos T
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Receptores de Antígenos de Linfócitos T gama-delta
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Sangue Fetal
Tipo de estudo:
Clinical_trials
Limite:
Female
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Humans
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Pregnancy
País como assunto:
Africa
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Europa
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article