Absence of arcuate fasciculus in children with global developmental delay of unknown etiology: a diffusion tensor imaging study.
J Pediatr
; 152(2): 250-5, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18206698
ABSTRACT
OBJECTIVE:
To investigate cortical association tracts using diffusion tensor imaging (DTI) in children with global developmental delay of unknown etiology. STUDYDESIGN:
We performed DTI in 20 patients (age range 18-83 months, mean 45 +/- 16 months, 12 males) with a history of global developmental delay and 10 typically developing children (age range 26-99 months, mean 54 +/- 24 months, 5 males). DTI tractography was performed to isolate major cortical association tracts.RESULTS:
In 9 out of 20 patients, arcuate fasciculus (AF) was absent bilaterally and in another 2 patients, it was absent in left hemisphere. In contrast, AF was present bilaterally in all typically developing children. Fractional Anisotropy (FA) of inferior longitudinal fasciculus (ILF) was asymmetric in the control group but not in the developmental delay group (P = .04). FA was significantly reduced in right ILF in developmentally delayed children compared with controls (P = .03). FA of other association tracts was not different between patients and controls (P = NS). The apparent diffusion coefficient (ADC) showed no asymmetry for these tracts in controls or developmentally delayed children (P = NS).CONCLUSIONS:
DTI can be used to identify absence of AF and inadequate maturation of ILF in children with global developmental delay of unknown etiology.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Deficiências do Desenvolvimento
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article