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Molecular mechanism of force generation by dynein, a molecular motor belonging to the AAA+ family.
Numata, Naoki; Kon, Takahide; Shima, Tomohiro; Imamula, Kenji; Mogami, Toshifumi; Ohkura, Reiko; Sutoh, Keiko; Sutoh, Kazuo.
Afiliação
  • Numata N; Department of Life Sciences, University of Tokyo, Komaba 3-8-1, Meguro, Tokyo 153-8902, Japan. numata@bio.c.u-tokyo.ac.jp
Biochem Soc Trans ; 36(Pt 1): 131-5, 2008 Feb.
Article em En | MEDLINE | ID: mdl-18208400
Dynein is an AAA+ (ATPase associated with various cellular activities)-type motor complex that utilizes ATP hydrolysis to actively drive microtubule sliding. The dynein heavy chain (molecular mass >500 kDa) contains six tandemly linked AAA+ modules and exhibits full motor activities. Detailed molecular dissection of this motor with unique architecture was hampered by the lack of an expression system for the recombinant heavy chain, as a result of its large size. However, the recent success of recombinant protein expression with full motor activities has provided a method for advances in structure-function studies in order to elucidate the molecular mechanism of force generation.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloendopeptidases / Dineínas Limite: Animals Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloendopeptidases / Dineínas Limite: Animals Idioma: En Ano de publicação: 2008 Tipo de documento: Article