Inorganic arsenic induces necrosis of human CD34-positive haematopoietic stem cells.
Environ Toxicol
; 23(2): 263-8, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-18214907
ABSTRACT
Inorganic arsenic is a major environmental contaminant known to exert immunosuppressive effects. In this study, we report toxicity of As2O3, a trivalent inorganic form, toward isolated human hematopoietic CD34+ progenitor cells. Our results demonstrate that low concentrations of As2O3 (0.1-5 microM) inhibit in vitro proliferation of CD34+ cells and their differentiation into various hematological cell lineages. These effects were associated with the induction of a necrotic process independent of caspases and likely related to mitochondrial damage. We conclude that As2O3 can impair in vitro human hematopoiesis by decreasing survival of CD34+ progenitor cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Óxidos
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Células-Tronco Hematopoéticas
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Diferenciação Celular
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Antígenos CD34
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Proliferação de Células
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Poluentes Ambientais
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article