Inhibition of tau aggregation in cell models of tauopathy.
Curr Alzheimer Res
; 4(5): 544-6, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-18220518
ABSTRACT
The pathological aggregation of tau into paired helical filaments is a hallmark of several neurodegenerative diseases, including Alzheimer's disease. We have generated cell models of tau aggregation in order to study mechanisms involving abnormal changes of tau. In the cell models the repeat domain of tau (tau(RD)) and some of its variants are expressed in a regulated fashion, e.g. the 4-repeat domain of tau with the wild-type sequence, the repeat domain with the deltaK280 mutation ("pro-aggregation mutant"), or the repeat domain with additional proline mutations ("anti-aggregation mutant"). The aggregation of tau(RD) is toxic to the cells, but aggregation and toxicity can be prevented by low molecular weight compounds identified by a screen for inhibitors. Thus the cell models are suitable for developing aggregation inhibitor drugs and testing their cellular roles.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas tau
/
Tauopatias
/
Modelos Biológicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article