Sickle cell patients are characterized by a reduced glycocalyx volume.
Haematologica
; 93(2): 307-8, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18245656
ABSTRACT
The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbSbeta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbSbeta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1 x 10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicocálix
/
Células Endoteliais
/
Anemia Falciforme
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article