[Influence of porcine pulmonary surfactant administered at different time on therapeutic effects in rats with oleic acid induced acute lung injury].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
; 20(2): 88-91, 2008 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-18279591
ABSTRACT
OBJECTIVE:
To investigate the therapeutic effects of endotracheal instillation porcine pulmonary surfactant (PPS) given at different time on acute lung injury (ALI) induced by oleic acid (OA).METHODS:
Arterial blood gases and respiratory rate during the experiments, survival rate, lung index, total protein (TP) contents in bronchoalveolar lavage fluid (BALF), tumor necrosis factor-alpha (TNF-alpha) level in plasma, light microscopy of the lung at 4 hours after the experiments were examined in different groups of Sprague-Dawley (SD) rats Group 1, sham group; Group 2, injected intravenously with OA 0.2 ml/kg; Group 3, injected intravenously with OA 0.2 ml/kg+PPS 100 mg/kg 0.5 hour after OA; Group 4, injected intravenously with OA 0.2 ml/kg+PPS 150 mg/kg 0.5 hour after OA; Group 5, injected intravenously with OA 0.2 ml/kg+PPS 100 mg/kg 2 hours after OA; Group 6, injected intravenously with OA 0.2 ml/kg+PPS 150 mg/kg 2 hours after OA.RESULTS:
Giving PPS not only improved the rats' (Group 3, Group 4 and Group 6) arterial blood gases and reduced respiratory rate, but also significantly raised their 4 hours-survival rate and decreased lung index, protein contents in BALF and TNF-alpha level in plasma, ameliorated pathohistological changes compared with Group 2 and Group 5 (all P<0.05).CONCLUSION:
PPS (100 mg/kg) administered at the early stage (0.5 hour after OA) provides obvious effects on respiratory efficiency and alleviates lung injury in rats with OA induced ALI, PPS (150 mg/kg) at the late stage (2 hours after OA) has the same effects mentioned above, however PPS (100 mg/kg) given 2 hours after ALI has no therapeutic effects.
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Base de dados:
MEDLINE
Assunto principal:
Surfactantes Pulmonares
/
Ácido Oleico
/
Lesão Pulmonar Aguda
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2008
Tipo de documento:
Article