N-myristoyltransferase: a novel target.
Mini Rev Med Chem
; 8(2): 142-9, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18289097
ABSTRACT
Myristoyl-CoAProtein N-myristoyltranferase (NMT) is a cytosolic monomeric enzyme which catalyses the transfer of a rare fatty acid, myristate from myristoyl-CoA to the N-terminal glycine residue of a variety of eukaryotic and viral proteins. N-myristoyltransferase is a novel target for anticancer, antiviral and antifungal agents. Recent N-myristoyltransferase inhibitors like benzofurans and benzothiazole derivatives show in vivo antifungal activity and are promising selective fungal N-myristoyltransferase inhibitors.
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Base de dados:
MEDLINE
Assunto principal:
Aciltransferases
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article