[Potential role of microRNAs in human diseases and the exploration on design of small molecule agents].
Yao Xue Xue Bao
; 42(11): 1115-21, 2007 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-18300464
ABSTRACT
MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene modulation by annealing to inexactly complementary sequences in the 3'-untranslated regions of target mRNAs. miRNA alterations are involved in the initiation and progression of human diseases. miRNA-expression profiling of human diseases has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. Recent evidence has suggested miRNAs as viable therapeutic targets for a wide range of human diseases. Several approaches were performed, the experimental examination of these techniques and the resultant findings not only indicate feasibility of interfering miRNA action in a gene-specific fashion but also may provide a new research tool for studying function of miRNAs. The new approaches also have the potential of becoming alternative gene therapy strategies.
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Base de dados:
MEDLINE
Assunto principal:
Perfilação da Expressão Gênica
/
Inativação Gênica
/
MicroRNAs
/
Cardiopatias
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article