Taurine activates glycine and gamma-aminobutyric acid A receptors in rat substantia gelatinosa neurons.
Neuroreport
; 19(3): 333-7, 2008 Feb 12.
Article
em En
| MEDLINE
| ID: mdl-18303577
ABSTRACT
Taurine has been suggested to modulate nociceptive information at the spinal cord level. In this study, the pharmacological properties of taurine were investigated in adult rat substantia gelatinosa (SG) neurons using whole-cell patch-clamp method. We found that taurine seemed to have higher efficacy than glycine on glycine receptors in SG neurons. An increase in chloride conductance was responsible for taurine-induced currents. Taurine at 0.3 mM activated glycine receptors, whereas at 3 mM activated both glycine and gamma-aminobutyric acid A receptors. The currents activated by coapplication of taurine and glycine are cross inhibitive. Altogether these results show that taurine might represent another important neurotransmitter or modulator in SG neurons, which may be involved in antinociception.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Substância Gelatinosa
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Taurina
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Receptores de Glicina
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Receptores de GABA-A
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Agonistas GABAérgicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article