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Phenylethynyl-pyrrolo[1,2-a]pyrazine: a new potent and selective tool in the mGluR5 antagonists arena.
Micheli, Fabrizio; Bertani, Barbara; Bozzoli, Andrea; Crippa, Luca; Cavanni, Paolo; Di Fabio, Romano; Donati, Daniele; Marzorati, Paola; Merlo, Giancarlo; Paio, Alfredo; Perugini, Lorenzo; Zarantonello, Paola.
Afiliação
  • Micheli F; GlaxoSmithKline, Psychiatry Centre of Excellence for Drug Discovery, Via Fleming 4, 37135 Verona, Italy. fm20244@gsk.com
Bioorg Med Chem Lett ; 18(6): 1804-9, 2008 Mar 15.
Article em En | MEDLINE | ID: mdl-18304814
ABSTRACT
The synthesis and the structure activity of a new series of pyrrolo[1,2-a]pyrazine is reported. These molecules are potent and selective non-competitive mGluR5 antagonists and may shed new light on the pattern of substitution tolerated by this receptor.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Pirróis / Receptores de Glutamato Metabotrópico Limite: Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Pirróis / Receptores de Glutamato Metabotrópico Limite: Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article