Postsplenectomy type-1 hypersensitivity response: a correlation between IL-4 and IgE serum levels.
Immunopharmacol Immunotoxicol
; 30(1): 71-7, 2008.
Article
em En
| MEDLINE
| ID: mdl-18306105
ABSTRACT
Authors demonstrated the presence of allergic manifestations in splenectomized patients following traumatic rupture of this organ. In particular, allergic diathesis, as supported by serum IgE increase, was exclusively found in patients with preserved T helper (h)-2 lymphocyte function. Th-2 function was monitored by measuring serum levels of interleukin (IL)-4, a cytokine involved in IgE synthesis. On the opposite, in splenectomized individuals with a reduced Th-2 function as supported by lower IL-4 serum levels, no IgE increase and allergic manifestations were detectable. On these grounds, authors hypothesize that allergic manifestations may be correlated to splenectomy since its exeresis may favor the persistence of antigens in the blood. Consequentially, in patients with a preserved Th-2 function, antigenic overload may lead to IgE increase and allergy onset.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Esplenectomia
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Imunoglobulina E
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Interleucina-4
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Hipersensibilidade Imediata
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Adult
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article