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Influence of intrauterine growth restriction on renal function in the adult rat.
Schreuder, M F; Van Wijk, J A E; Fodor, M; Delemarre-van de Waal, H A.
Afiliação
  • Schreuder MF; Department of Pediatric Nephrology, VU University Medical Center, Amsterdam, The Netherlands. m.f.schreuder@erasmusmc.nl
J Physiol Biochem ; 63(3): 213-9, 2007 Sep.
Article em En | MEDLINE | ID: mdl-18309777
Intrauterine growth restriction (IUGR) has been shown to influence renal development and lead to fewer nephrons. Data on long term renal function after IUGR are limited. We studied the effect on renal function of IUGR in aging rats. IUGR was induced using a model of bilateral uterine artery ligation in pregnant Wistar rats. Renal function was studied at the age of 18 months. In male IUGR rats, estimated glomerular filtration rate was significantly decreased compared to male control rats [1.1 (SD 0.3) 1.7 (SD 0.3) ml x min(-1), p<0.05]. Female IUGR rats showed an increased urinary protein excretion compared with female control rats [84 (SD 73) vs. 12 (SD 13) mg x 24h(-1), p<0.01]. All male rats showed heavy proteinuria (p<0.01 vs. female rats from same experimental group), with no significant differences between the groups. Tubular reabsorption of phosphorus was lower in females, but showed no differences between the experimental groups. In conclusion, IUGR impairs renal function in the rat. It is suggested that a low nephron endowment leads to proteinuria as a sign of glomerular damage, and ends with a decrease in glomerular filtration rate as a sign of glomerular loss.
Assuntos
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Base de dados: MEDLINE Assunto principal: Retardo do Crescimento Fetal / Rim Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2007 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Retardo do Crescimento Fetal / Rim Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2007 Tipo de documento: Article