An assessment of neutrophils/lymphocytes ratio in patients suspected of acute coronary syndrome.
Arq Bras Cardiol
; 90(1): 31-6, 2008 Jan.
Article
em En, Pt
| MEDLINE
| ID: mdl-18317638
ABSTRACT
BACKGROUND:
Leukocytes total count is an independent risk marker for cardiovascular events. The ratio between neutrophils and lymphocytes (N/L) count has been investigated as a new predictor for cardiovascular risk, although its diagnostic role when assessing patients suspected of an acute coronary syndrome (ACS) condition is not yet known.OBJECTIVE:
To evaluate the diagnostic power of N/L ratio in patients who have been admitted at a Chest Pain Unit (CPU) with the suspicion of ACS.METHODS:
Evaluation was conducted in 178 patients admitted with chest pain. Diagnostic flowchart including clinical, electrocardiographic, and laboratory data. Diagnosis obtained was acute myocardial infarction (AMI) with (AMI-STE) and with no segment T elevation (AMI-NSTE), unstable angina (UA ) and non-cardiac pain (NC). Total and differential leukocyte count was conducted in peripheral blood sample collected at admission.RESULTS:
Patients diagnosed with non-cardiac pain reported the lowest N/L ratio (n=45; 3.0 +/- 1.6), followed by UA (n=65; 3.6 +/- 2.9), AMI-NSTE (n=33; 4.8 +/- 3.7) and AMI-STE (n=35; 6.9 +/- 5.7); p < 0.0001. N/L ratio above 5.7 (highest quartile) reported 91.1% specificity, 4.51 odds ratio (CI 95% 1.51 to 13.45) for the final diagnosis of ACS when compared to the groups at lower quartiles.CONCLUSION:
The N/L ratio presents correlation with final diagnosis of patients with suspicion of ACS at admission. Considering this is a low cost, good reproductibility test, new studies should ellucidate whether the ratio may be of relevance for diagnosis flowcharts currently in use.
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Base de dados:
MEDLINE
Assunto principal:
Dor no Peito
/
Linfócitos
/
Síndrome Coronariana Aguda
/
Angina Instável
/
Infarto do Miocárdio
/
Neutrófilos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
/
Pt
Ano de publicação:
2008
Tipo de documento:
Article