5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: initiating a quest for new antitubercular drugs.
J Med Chem
; 51(7): 1999-2002, 2008 Apr 10.
Article
em En
| MEDLINE
| ID: mdl-18335974
ABSTRACT
Pantothenate synthetase (PS) is one of the potential new antimicrobial targets that may also be useful for the treatment of the nonreplicating persistent forms of Mycobacterium tuberculosis. In this Letter we present a series of 5- tert-butyl- N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[ d]isoxazole-3-carboxamide derivatives as novel potent Mycobacterium tuberculosis PS inhibitors, their in silico molecular design, synthesis, and inhibitory activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeo Sintases
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Pirazóis
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Inibidores Enzimáticos
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Isoxazóis
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Mycobacterium tuberculosis
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Antituberculosos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article