Aliskiren: the first renin inhibitor for clinical treatment.
Nat Rev Drug Discov
; 7(5): 399-410, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18340340
ABSTRACT
The first evidence of the existence of renin was presented over 100 years ago. However, the importance of renin and the renin-angiotensin system in the pathogenesis of cardiovascular disease was only fully realized in the 1970s. It was another 20 years before the first inhibitors of renin were available for clinical research. Here, we describe the discovery and development of aliskiren, an orally active renin inhibitor, which became the first drug in its class to receive regulatory approval. In 2007, it was approved for the treatment of hypertension by the US Food and Drug Administration and the European Medicines Agency.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Renina
/
Fumaratos
/
Amidas
/
Hipertensão
/
Anti-Hipertensivos
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article