Octamers and nanoparticles as hemoglobin based blood substitutes.
Biochim Biophys Acta
; 1784(10): 1448-53, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18342640
ABSTRACT
Progress in developing a blood substitute is aided by new biotechnologies and a better understanding of the circulatory system. For Hb based solutions, there is still a debate over the best set of fundamental parameters concerning the oxygen affinity which is correlated with the oxidation rate, the cooperativity, the transporter size, and of course the final source of material. Genetic engineering methods have helped discover novel globins, but not yet the quantity necessary for the high demand of blood transfusions. The expanding database of globin properties has indicated that certain individual parameters are coupled, such as the oxygen affinity and the oxidation rate, indicating that one must accept a compromise of the best parameters. After a general introduction of these basic criteria, we will focus on two strategies concerning the size of the oxygen transporter Hb octamers, and Hb integrated within a nanoparticle.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Substitutos Sanguíneos
/
Hemoglobinas
/
Nanopartículas
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article