Molecular and genetic changes in asbestos-related lung cancer.
Cancer Lett
; 265(1): 1-15, 2008 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-18364247
ABSTRACT
Asbestos-exposure is associated with an increased risk of lung cancer, one of the leading causes of cancer deaths worldwide. Asbestos is known to induce DNA and chromosomal damage as well as aberrations in signalling pathways, such as the MAPK and NF-kappaB cascades, crucial for cellular homeostasis. The alterations result from both indirect effects through e.g. reactive oxygen/nitrogen species and direct mechanical disturbances of cellular constituents. This review describes the current knowledge on genomic and pathway aberrations characterizing asbestos-related lung cancer. Specific asbestos-associated molecular signatures can assist the development of early biomarkers, molecular diagnosis, and molecular targeted treatments for asbestos-exposed lung cancer patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Amianto
/
Transformação Celular Neoplásica
/
Aberrações Cromossômicas
/
Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article