State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells.
Neuron
; 57(6): 905-16, 2008 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-18367091
ABSTRACT
Cortical pyramidal neurons alter their responses to input signals depending on behavioral state. We investigated whether changes in somatic inhibition contribute to these alterations. In layer 5 pyramidal neurons of rat visual cortex, repetitive firing from a depolarized membrane potential, which typically occurs during arousal, produced long-lasting depression of somatic inhibition. In contrast, slow membrane oscillations with firing in the depolarized phase, which typically occurs during slow-wave sleep, produced long-lasting potentiation. The depression is mediated by L-type Ca2+ channels and GABA(A) receptor endocytosis, whereas potentiation is mediated by R-type Ca2+ channels and receptor exocytosis. It is likely that the direction of modification is mainly dependent on the ratio of R- and L-type Ca2+ channel activation. Furthermore, somatic inhibition was stronger in slices prepared from rats during slow-wave sleep than arousal. This bidirectional modification of somatic inhibition may alter pyramidal neuron responsiveness in accordance with behavioral state.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Córtex Visual
/
Células Piramidais
/
Dendritos
/
Inibição Neural
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article