Leser-Trelat sign in metastasized malignant melanoma.
Eur Arch Otorhinolaryngol
; 266(2): 297-9, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-18369652
ABSTRACT
The Leser-Trelat sign is defined as the association of multiple, eruptive seborrheic keratoses with an internal malignancy of a usually advanced stage. We report the case of malignant melanoma in an 82-year-old man covered with hundreds of greyish-dark seborrheic keratoses resembling a Christmas tree pattern, who was diagnosed with metastasized malignant melanoma involving the parotid gland and lymph nodes. Though the pathogenesis of Leser-Trelat sign is still unknown, spontaneous regression of the seborrheic keratoses following tumor reduction described in some cases argues for a paraneoplastic origin of this highly instructive clinical entity. Physicians should consider a workup for internal malignancy in patients presenting with multiple eruptive seborrheic keratoses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndromes Paraneoplásicas
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Neoplasias Cutâneas
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Ceratose Seborreica
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Melanoma
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged80
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Humans
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Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article