Targeting intracellular signaling: a novel approach to vaccination.
Expert Rev Vaccines
; 6(6): 971-80, 2007 Dec.
Article
em En
| MEDLINE
| ID: mdl-18377359
ABSTRACT
Vaccination is well known to control many current infectious diseases. However, the development of cellular (Th1) immunity to control viral pathogens, among others, requires the development of new vaccine adjuvants. The use of Toll-like receptor ligands or cytokines has shown much promise, although specificity and toxicity are issues with these strategies. Targeting intracellular signaling pathways may allow for greater specificity of the adjuvant, as well as reducing systemic toxicity. Studies targeting these pathways are discussed, as well as their potential applications in the future.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas
/
Transdução de Sinais
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Vacinação
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Sistemas de Liberação de Medicamentos
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Líquido Intracelular
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article