5-HT1A-agonistic properties of naftopidil, a novel antihypertensive drug.
Eur J Pharmacol
; 205(1): 105-7, 1991 Nov 19.
Article
em En
| MEDLINE
| ID: mdl-1839829
ABSTRACT
Naftopidil, a novel antihypertensive compound, possesses 5-HT1A agonistic properties in addition to being an alpha 1-adrenoceptor antagonist. The IC50 values for alpha 1-adrenoceptors (235 nmol/l) and for 5-HT1A receptors (108 nmol/l) lie in the same concentration range. The reduction in blood pressure of anesthetized cats by 8-OH-DPAT and urapidil was completely abolished by spiroxatrine, a 5-HT1A antagonist. However, the decreases in blood pressure induced by naftopidil were only partly antagonized by spiroxatrine.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Receptores de Serotonina
/
Naftalenos
/
Anti-Hipertensivos
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article