Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.
Bioorg Med Chem Lett
; 18(9): 2920-3, 2008 May 01.
Article
em En
| MEDLINE
| ID: mdl-18407496
ABSTRACT
We describe herein the discovery and development of a series of 4-arylthieno[3,2-d]pyrimidines which are potent adenosine A(2A) receptor antagonists. These novel compounds show high degrees of selectivity against the human A(1), A(2B) and A(3) receptor sub-types. Moreover, a number of these compounds show promising activity in vivo, suggesting potential utility in the treatment of Parkinson's disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Desenho de Fármacos
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Transtornos Parkinsonianos
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Antagonistas do Receptor A2 de Adenosina
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Antiparkinsonianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article