P2Y1 receptor antagonists as novel antithrombotic agents.
Bioorg Med Chem Lett
; 18(11): 3338-43, 2008 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-18445527
ABSTRACT
The P2Y(1) and P2Y(12) purinergic receptors are responsible for mediating adenosine diphosphate (ADP) dependent platelet aggregation. Evidence from P2Y(1) knockout studies as well as from nucleotide-based small molecule P2Y(1) antagonists has suggested that the antagonism of this receptor may offer a novel and effective method for the treatment of thrombotic disorders. Herein, we report the identification and optimization of a series of non-nucleotide P2Y(1) antagonists that are potent and orally bioavailable.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antagonistas do Receptor Purinérgico P2
/
Fibrinolíticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article