The effect of pegylated interferon-alpha2b and ribavirin on posttraumatic stress disorder symptoms.
Psychosomatics
; 49(3): 225-9, 2008.
Article
em En
| MEDLINE
| ID: mdl-18448777
ABSTRACT
BACKGROUND:
Patients with chronic psychiatric diagnoses have a prevalence of chronic hepatitis C (HCV) approximately 11 times higher than the general American population. Posttraumatic stress disorder (PTSD) is particularly common among HCV patients.OBJECTIVE:
The authors describe the effect of treatment with pegylated-interferon-alpha(2b) (IFN) and ribavirin for patients with HCV on their posttraumatic stress disorder (PTSD) symptoms.METHOD:
Sixteen patients with HCV and combat-related PTSD were followed for 24 weeks and assessed with self-report measures of PTSD, hostility, and depression.RESULTS:
Depression and Resentment scores significantly increased in five patients treated with IFN and ribavirin, but no significant differences were found in PTSD scores when compared with 11 control patients.CONCLUSION:
The results suggest that patients with PTSD and HCV can be safely treated with anti-viral therapies when they are given appropriate psychiatric care.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Ribavirina
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Transtornos de Estresse Pós-Traumáticos
/
Interferon-alfa
/
Hepatite C Crônica
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
/
Screening_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article