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DNAM-1: an amplifier of immune responses as a therapeutic target in various disorders.
Elishmereni, Moran; Bachelet, Ido; Levi-Schaffer, Francesca.
Afiliação
  • Elishmereni M; The Hebrew University of Jerusalem, Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, POB 12065, Jerusalem 91120, Israel.
Curr Opin Investig Drugs ; 9(5): 491-6, 2008 May.
Article em En | MEDLINE | ID: mdl-18465659
The co-stimulatory adhesion molecule DNAX accessory molecule 1 (DNAM-1) is a functional glycoprotein expressed on immune cells, such as natural killer and T-cells. It is activated upon interaction with its biological ligands, the poliovirus receptor and nectin-2. Signaling cascades involving stimulation of DNAM-1 lead to various biological responses, including target cell lysis and immune cell activation. Thus, DNAM-1 appears to be an integral molecule in immune responses in cancer, allergic inflammatory disorders and autoimmune diseases. The structure of DNAM-1, its mechanism of action and its effects in pathological scenarios are discussed.
Assuntos
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Base de dados: MEDLINE Assunto principal: Antígenos de Diferenciação de Linfócitos T / Moléculas de Adesão Celular Limite: Animals / Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Antígenos de Diferenciação de Linfócitos T / Moléculas de Adesão Celular Limite: Animals / Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article