Mortality among workers exposed to acrylonitrile in fiber production: an update.
J Occup Environ Med
; 50(5): 550-60, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18469624
ABSTRACT
OBJECTIVE:
The investigation updates the mortality experience through 2002 for a cohort of workers exposed to acrylonitrile (AN).METHODS:
Standardized mortality ratios (SMR) were estimated based on two reference populations the US population and a regional employee population. Exposure-response analyses were conducted using Cox regression models for cumulative and mean intensity exposure measures.RESULTS:
In the cohort of 2548 workers, 839 deaths have occurred with 91 deaths due to respiratory system cancer. Most standardized mortality ratio estimates are at or near no-effects levels. Hazard ratio (HR) estimates indicate no increased mortality risk for respiratory system cancer (adjusted HR = 0.96, 95% confidence interval 0.74, 1.25).CONCLUSIONS:
In summary, no mortality outcome of a priori interest, principally respiratory system cancer, is associated with increased AN exposure among fiber production workers over five decades of follow-up.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acrilonitrila
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Carcinógenos
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Indústria Química
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Exposição Ocupacional
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Neoplasias
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Humans
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Male
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Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article