Lipopolysaccharide-induced monocytic cell death for the diagnosis of mild neonatal-onset multisystem inflammatory disease.
J Pediatr
; 152(6): 885-7, 887.e1, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18492537
ABSTRACT
In this report, we describe a boy who showed mild symptoms of neonatal-onset multisystem inflammatory disease. Although his symptoms and laboratory findings were similar to those of systemic juvenile idiopathic arthritis, further examinations revealed papilledema, meningitis, and a NLRP3 mutation. His peripheral blood monocytes died within 24 hours after lipopolysaccharide stimulation, a test that may be useful for diagnosis even in mild cases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Monócitos
/
Lipopolissacarídeos
/
Inflamação
Tipo de estudo:
Diagnostic_studies
Limite:
Child
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article