Mitochondrial AIF protein involved in skeletal muscle regeneration.
Cell Biochem Funct
; 26(5): 598-602, 2008.
Article
em En
| MEDLINE
| ID: mdl-18508388
ABSTRACT
The mitochondrial flavoprotein apoptosis-inducing factor (AIF) has proved to be either the main mediator of apoptosis or an anti-apoptotic factor via its putative oxidoreductase and peroxide scavenging activities. We report here that 100 muM hydrogen peroxide (H2O2) induced the proliferation of C2C12 myoblasts and over-expression of AIF simultaneously in vitro. Immunofluorescence showed that the over-expression of AIF was located in the cytoplasm. The immunopositive AIF was detected in nuclei 27 days after denervation of skeletal muscle, but in the cytoplasm it was detected 27 days after fiber-damaged skeletal muscle. AIF may be a factor involved in skeletal muscle regeneration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Músculo Esquelético
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Proteínas Mitocondriais
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Desenvolvimento Muscular
/
Fator de Indução de Apoptose
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article