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Platelet [3H]imipramine and alpha 2-adrenoceptor binding in normal subjects during desipramine administration and withdrawal.
Healy, D T; Paykel, E S; Whitehouse, A M; White, W; Wilton-Cox, H; Johnson, A L; Theodorou, A E; Lawrence, K; Horton, R W.
Afiliação
  • Healy DT; Department of Psychiatry, University of Wales, Clwyd, UK.
Neuropsychopharmacology ; 4(2): 117-24, 1991 Feb.
Article em En | MEDLINE | ID: mdl-1851012
The effect of desipramine 150 mg daily on platelet [3H]imipramine and alpha 2-adrenoceptor binding sites was studied over a 6-week period and for 6 weeks after withdrawal. Modest (10%) increases in [3H]imipramine binding site densities during treatment were noted with a decrease between 1 and 4 weeks after withdrawal. No effect was found on alpha 2-adrenoceptors. Time of day appeared to have some effect on the results found. None of the [3H]imipramine binding site effects of desipramine, on treatment or following withdrawal, was comparable in magnitude to trait differences that were also found between subjects.
Assuntos
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Base de dados: MEDLINE Assunto principal: Plaquetas / Receptores Adrenérgicos alfa / Desipramina / Imipramina Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 1991 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Plaquetas / Receptores Adrenérgicos alfa / Desipramina / Imipramina Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 1991 Tipo de documento: Article